Perhaps the most serious problem which we have encountered in the synthesis of oligonucleotides by the phosphotriester approach with phenyl and other aryl protecting groups'. is the internucleotide cleavage which accompanies the removal of the latter protecting groups. For example, in a recent stu
โฆ LIBER โฆ
Oximate ion promoted unblocking of oligonucleotide phosphotriester intermediates
โ Scribed by Colin B. Reese; Richard C. Titmas; Laval Yau
- Publisher
- Elsevier Science
- Year
- 1978
- Tongue
- French
- Weight
- 292 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0040-4039
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