Oxidized phospholipids in control of inflammation and endothelial barrier
✍ Scribed by Panfeng Fu; Konstantin G. Birukov
- Book ID
- 118253677
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 260 KB
- Volume
- 153
- Category
- Article
- ISSN
- 1931-5244
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## Abstract Oxidized 1‐palmitoyl‐2‐arachidonoyl‐__sn__‐glycero‐3‐phosphorylcholine (OxPAPC) exhibits potent barrier protective effects on pulmonary endothelium, which are mediated by small GTPases Rac and Cdc42. However, upstream mechanisms of OxPAPC‐induced small GTPase activation are not known. W
## Abstract Afadin is a novel regulator of epithelial cell junctions assembly. However, its role in the formation of endothelial cell junctions and the regulation of vascular permeability remains obscure. We previously described protective effects of oxidized 1‐palmitoyl‐2‐arachidonoyl‐__sn__‐glyce