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Oxidized LDL Induces an Oxidative Stress and Activates the Tumor Suppressor p53 in MRC5 Human Fibroblasts

✍ Scribed by Cécile Mazière; Arnaud Meignotte; Françoise Dantin; Marie-Alix Conte; Jean-Claude Mazière


Book ID
115586608
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
176 KB
Volume
276
Category
Article
ISSN
0006-291X

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We introduced the mutant p53 zene (codon 273Ar9-His) into human fibroblasts (SUSM-I ceils) previously immortalized with 4-nitroquinoline I -oxide (4NQO) and obtained 2 clonal cell lines (SUSM-I /p53-I and SUSM-l/p53-6) expressing the mutant p53. Since the genetic background of SUSM-l/p53 is the same