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Oxidized LDL immune complexes induce release of sphingosine kinase in human U937 monocytic cells

โœ Scribed by Samar M. Hammad; Tarek A. Taha; Alena Nareika; Korey R. Johnson; Maria F. Lopes-Virella; Lina M. Obeid


Book ID
113864965
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
572 KB
Volume
79
Category
Article
ISSN
0090-6980

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Human monocytic leukemia U937 cells undergo apoptosis when treated with antitumor drugs, such as etoposide, camptothecin and mitomycin C. The molecular mechanism of the drug-induced apoptosis is not well understood. In this study, we found that 2-deoxyglucose (2DG), an analog of D-glucose and an ind