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Oxidative Synthesis of α-Amino Nitriles from Tertiary Amines

✍ Scribed by Michael North


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
134 KB
Volume
43
Category
Article
ISSN
0044-8249

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One-Pot Synthesis of Trisubstituted 1,2-
✍ Coralie Kison; Till Opatz 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 159 KB

## Abstract A short synthesis of __N__,1,2‐trisubstituted vicinal amino alcohols by 1,2‐addition of deprotonated __N__‐monosubstituted α‐amino nitriles to aldehydes and subsequent one‐pot reduction of the intermediates with borane–THF is described. This procedure leads to the predominant formation