Multiple low-dose and single high-dose t
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Gianpaolo Papaccio; Francesco Aurelio Pisanti; Michael V.G. Latronico; Eduardo A
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Article
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2000
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John Wiley and Sons
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English
β 306 KB
Streptozotocin (STZ) is a widely used diabetogenic agent that damages pancreatic islet β€ cells by activating immune mechanisms, when given in multiple low doses, and by alkylating DNA, when given at a single high dose. Actually, STZ contains a nitroso moiety. Incubation of rat islets with this compo