Oxidative stress, nitric oxide, and the mechanisms of cell death in Lurcher Purkinje cells
β Scribed by Rebecca McFarland; Andrei Blokhin; James Sydnor; Jean Mariani; Michael W. Vogel
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 2007
- Tongue
- English
- Weight
- 703 KB
- Volume
- 67
- Category
- Article
- ISSN
- 1932-8451
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In the present study we examined the effect of oxidative stress-mediated hydroperoxide formation on the activity of nitric oxide synthase (NOS) in retinal cells in culture. Oxidative stress was induced in the presence of Fe 2Ψ and ascorbate or Fe 2Ψ alone and compared to H 2 O 2 -induced maximal cel
When cultured cerebellar granule neurons (CGN) are transferred from 25 mM KCl (K25) to 5 mM KCl (K5) caspase-3 and caspase-8, but not caspase-1 or caspase-9,activities are induced and cells die apoptotically. CGN death was triggered by a [Ca(2+)](i) modification when [Ca(2+)](i) was reduced from 300
## Abstract Neuronal death, attributable to perturbed redox homeostasis, is the underlying factor in many acute and chronic neurological disorders. The mechanisms employed by oxidatively stressed neurons to commit to cell death pathways are beginning to be characterized, but this is hampered by a l