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Oxidative stress mechanisms and potential therapeutics in Alzheimer disease

✍ Scribed by P. I. Moreira; S. L. Siedlak; G. Aliev; X. Zhu; A. D. Cash; M. A. Smith; G. Perry

Publisher: Springer
Year: 2004
Tongue: English
Weight: 87 KB
Volume: 112
Category: Article
ISSN: 1435-1463
DOI: 10.1007/s00702-004-0242-8

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## Abstract Alzheimer's disease (AD) is a dementing neurodegenerative disorder without a cure. The abnormal parenchymal accumulation of β‐amyloid (Aβ) is associated with inflammatory reactions involving microglia and astrocytes. Increased levels of Aβ and Aβ deposition in the brain are thought to c