Oxidative stress and uremia

✍ Scribed by Fulvio Floccari; Carmela Aloisi; Eleonora Crascì; Tito Sofi; Susanna Campo; Donatella Tripodo; Manila Criseo; Nicola Frisina; Michele Buemi

• Book ID: 102506266
• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: English
• Weight: 134 KB
• Volume: 25
• Category: Article
• ISSN: 0198-6325
• DOI: 10.1002/med.20028

✦ Synopsis

Abstract

Oxidative stress is a pathogenic element of great importance in uremic patients, with a great impact on their survival. The cause of oxidative stress in patients on hemodialysis is traditionally attributed to the recurrent activation of polymorphonucleate neutrophils and monocytes. The effects of oxidative stress are evident on all biochemical components of biological tissues: lipids, proteins, carbohydrates, and nucleic acids. This study briefly reviews the effects of different dialytic techniques and of kidney transplant on several parameters of oxidative stress. Many different modalities of pharmaceutical intervention are then analyzed, and the clinical evidences reported. © 2005 Wiley Periodicals, Inc.