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Oxidative stress and enhanced paracellular permeability in the small intestine of methotrexate-treated rats

✍ Scribed by Tomoko Maeda; Yuko Miyazono; Kousei Ito; Kazuma Hamada; Shuichi Sekine; Toshiharu Horie

Publisher
Springer
Year
2009
Tongue
English
Weight
354 KB
Volume
65
Category
Article
ISSN
0344-5704

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The objective of this study was to mechanistically and quantitatively analyze chenodeoxycholate-enhanced paracellular transport of polar permeants and oligonucleotides in the rat jejunum and ileum. Micellar chenodeoxycholate solutions were used to perturbate the tight junctions. Supporting studies i