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Oxidative state and IL-6 production in intestinal myofibroblasts of Crohn's disease patients

✍ Scribed by Serena Catarzi; Fabio Favilli; Cecilia Romagnoli; Tommaso Marcucci; Lucia Picariello; Francesco Tonelli; Maria Teresa Vincenzini; Teresa Iantomasi

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
531 KB
Volume
17
Category
Article
ISSN
1078-0998

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✦ Synopsis

Background: Intestinal subepithelial myofibroblasts (ISEMFs) produce inflammatory cytokines in response to certain stimuli. In the intestine of patients with Crohn's disease (CD), cytokine synthesis is modified and an increased number of myofibroblasts has been observed. The intracellular redox state influences cytokine production and oxidative stress is present in the intestinal mucosa of CD patients.

Conclusions:

This study shows for the first time in ISEMFs of CD patients an increased production of IL-6 synthesis related to the decrease in the GSH/GSSH ratio, suggesting redox regulation with the involvement of specific kinase activation. The present data shed light on the pathogenesis of inflammatory chronic processes and relapses that occur in this pathology.

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