Intracellular recordings were made from hippocampal CA1 pyramidal cells in slices where the CA3/CA4 region had been lesioned using intracerebroventricular kainic acid. In 55% of the cells studied orthodromic excitation evoked bursts of action potentials. This bursting activity was associated with a
✦ LIBER ✦
Oxidative modulation of the transient potassium current IA by intracellular arachidonic acid in rat CA1 pyramidal neurons
✍ Scribed by Plamena Angelova; Wolfgang Müller
- Book ID
- 109024414
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 332 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0953-816X
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## Abstract Pituitary adenylate cyclase‐activating polypeptide (PACAP), a neurotrophic and neuromodulatory peptide, was recently shown to enhance NMDA receptor‐mediated currents in the hippocampus (Macdonald, et al. 2005. J Neurosci 25:11374–11384). To check if PACAP might also modulate AMPA recept