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Oxidative metabolites of 5-S-cysteinyldopamine inhibit the pyruvate dehydrogenase complex

โœ Scribed by H. Li; G. Dryhurst


Publisher
Springer
Year
2001
Tongue
English
Weight
246 KB
Volume
108
Category
Article
ISSN
1435-1463

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The อฐ-cyano-อฑ-hydroxy enamide 1 is an inhibitor of human dihydroorotate dehydrogenase (IC 50 ฯญ 0.26 ศM), the rate-limiting enzyme in the de novo pyrimidine biosynthesis. A structure-activity analysis based on selected derivatives of 1 demonstrates that both its structural characteristics and its phy