Metabolic activations of polycyclic hydr
β
Roland E. Lehr; Donald M. Jerina
π
Article
π
1977
π
Springer-Verlag
π
English
β 340 KB
Considerable evidence now points to 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrenes as ultimate mutagenic and carcinogenic forms of benzo(a)-pyrene. Quantum mechanical calculations have been performed to assess the possible general role of diol epoxides in polycyclic aromatic hydrocarbon