Oxidative enzymes of polymorphonuclear leucocytes and plasma fibrinogen, ceruloplasmin, and copper levels in Behcet's disease

✍ Scribed by Pakize Doğan; Gürsel Tanrikulu; Ümit Soyuer; Kader Köse

• Book ID: 103040624
• Publisher: Elsevier Science
• Year: 1994
• Tongue: English
• Weight: 673 KB
• Volume: 27
• Category: Article
• ISSN: 0009-9120
• DOI: 10.1016/0009-9120(94)90046-9

✦ Synopsis

This study was performed to investigate the antioxident mechanisms of polymorphonuclear leucocytes (PMN) in active stage of Behget's Disease. PMN activities of myeloperoxidase (p < 0.02), superoxide dlsmutase (p < 0.001), catalase (p < 0.005), and glutathlone peroxidsee (p < 0.005) were significantly lower in the patients: the NADPH oxidase activity was significantly hlgher (p < 0.001) than those in controls. The plasma levels of ceruloplasmln (Cp), flbrinogen, and copper (Cu) were also signiflcantly higher in the patients group (p < 0.001). Slgnlflcant and poslUve correlations were found between the glutathione peroxldsee and catslase activities (p < 0.001) and also between the plasma Cp and Cu levels (p < 0.001) in the patients group. However, no correlation was observed among the other enzyme activities. In the control group, a significantly positive correlatlon was present only between the plasma ceruloplasmin and Cu levels (p < 0.001). It was concluded that (impaired PMN functions) decreased enzyme activities in the antioxidant system and Increased levels of oxygen free radicals may play a role in tissue damage in Sehget's disease.