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Oxidative DNA Damage in Human Respiratory Tract Epithelial Cells. Time Course in Relation to DNA Strand Breakage

✍ Scribed by Jeremy P.E. Spencer; Andrew Jenner; Okezie I. Aruoma; Carroll E. Cross; Reen Wu; Barry Halliwell


Book ID
115578649
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
91 KB
Volume
224
Category
Article
ISSN
0006-291X

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## Abstract The mechanism of Cr(VI) genotoxicity has still not been elucidated. We used Fpg‐modified comet assay to assess direct‐oxidative DNA damage on human lung (A549) and bronchial (BEAS‐2B) cells exposed to 0.1, 0.5, 1.0 and 10 μm sodium chromate for 0.5, 1 and 4 h. Moreover we evaluated apop