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Oxidative DNA base damage and antioxidant enzyme levels in childhood acute lymphoblastic leukemia

✍ Scribed by Sema Sentürker; Bensu Karahalil; Mine Inal; Hülya Yilmaz; Hamza Müslümanoglu; Gündüz Gedikoglu; Miral Dizdaroglu

Book ID
117108311
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
513 KB
Volume
416
Category
Article
ISSN
0014-5793

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The interindividual variation in the activity of xenobiotic metabolizing enzymes and DNA repair genes could modify an individual's risk of recurrent malignancy and response to therapy. We investigated whether ALL outcome was related to polymorphisms in genes CYP2D6, MPO, EPHX1, NQO1, TS, XPD and XRC