𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Oxidative degradation of pharmaceuticals: Theory, mechanisms and inhibition

✍ Scribed by Susan W. Hovorka; Christian Schöneich

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
297 KB
Volume
90
Category
Article
ISSN
0022-3549

No coin nor oath required. For personal study only.

✦ Synopsis

Oxidation is a common pathway for drug degradation in liquid and solid formulations. The present article reviews mechanistic details of autoxidation and chain oxidation processes, as well as the oxidation of selected functional groups commonly affected in drugs.

📜 SIMILAR VOLUMES

Oxidative degradation of pharmaceuticall
Oxidative degradation of pharmaceutically important phenothiazines III: Kinetics and mechanism of promethazine oxidation
✍ W. J. M. Underberg 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 English ⚖ 589 KB

The kinetics of the thermal degradation of promethazine in an acidic medium under various conditions were investigated. The degradation of promethazine and the formation of some degradation products were studied under aerobic and anaerobic conditions. The influence of pH, metal ions such as copper(I

The mechanism of oxidative degradation o
The mechanism of oxidative degradation of ABS resin. Part I. The mechanism of thermooxidative degradation
✍ Junichi Shimada; Kimiaki Kabuki 📂 Article 📅 1968 🏛 John Wiley and Sons 🌐 English ⚖ 548 KB

In this work the early stages of the thermal oxidation of ABS resin flms for commercial utilization and purified samples were studied by means of infrared spectroscopy. The film samples were submitted to thermal oxidation .in a Gear oven a t 70-90'C. During the aging in the Gear oven the nitrile and