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Oxidative Damage to Nucleic Acids in Human Prion Disease

✍ Scribed by Marin Guentchev; Sandra L. Siedlak; Christa Jarius; Fabrizio Tagliavini; Rudy J. Castellani; George Perry; Mark A. Smith; Herbert Budka


Book ID
115641696
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
363 KB
Volume
9
Category
Article
ISSN
0969-9961

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## Abstract Oxidative damage to DNA appears to be a factor in cancer, yet explanations for why highly elevated levels of such lesions do not always result in cancer remain elusive. Much of the genome is non‐coding and lesions in these regions might be expected to have little biological effect, an i