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Oxidative Damage of Mitochondria Induced by Fe(II)Citrate Is Potentiated by Ca2+ and Includes Lipid Peroxidation and Alterations in Membrane Proteins

✍ Scribed by R.F. Castilho; A.R. Meinicke; A.M. Almeida; M. Hermeslima; A.E. Vercesi


Book ID
115564798
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
561 KB
Volume
308
Category
Article
ISSN
0003-9861

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Oxidative damage to sarcoplasmic reticul
✍ Roger F. Castilho; Paulo C. Carvalho-Alves; Anibal E. Vercesi; SΓ©rgio T. Ferreir πŸ“‚ Article πŸ“… 1996 πŸ› Springer 🌐 English βš– 904 KB

The major protein in the sarcoplasmic reticulum (SR) membrane is the Ca2+ transporting ATPase which carries out active Ca2+ pumping at the expense of ATP hydrolysis. The aim of this work was to elucidate the mechanisms by which oxidative stress induced by Fenton's reaction (Fe(2+)+H2O2-->HO.+OH-+Fe3