Oxidative damage and stress response from ochratoxin a exposure in rats
✍ Scribed by Jean-Charles Gautier; Daisy Holzhaeuser; Jovanka Markovic; Eric Gremaud; Benoı̂t Schilter; Robert J Turesky
- Book ID
- 114274723
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 889 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0891-5849
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📜 SIMILAR VOLUMES
## Abstract The aim of this study was to find out whether very low doses of nephrotoxic and hepatotoxic mycotoxins ochratoxin A (OTA) and fumonisin B~1~ (FB~1~) induce oxidative stress in rat kidney and liver and whether their effect is synergistic. Rats were treated orally with OTA (5 ng/kg b.w. a
The nephrotoxic/carcinogenic mycotoxin ochratoxin A (OTA) occurs as a contaminant in food and feed and may be linked to human endemic Balkan nephropathy. The mechanism of OTA-derived carcinogenicity is still under debate, since reactive metabolites of OTA and DNA adducts have not been unambiguously