Oxidative chlorination of [U-14C] phenol

✍ Scribed by D. Georgin; S. de Suzzoni-Dezard; J. P. Noel

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: French
• Weight: 282 KB
• Volume: 38
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/(sici)1099-1344(199607)38:7<645::aid-jlcr879>3.0.co;2-4

✦ Synopsis

The preparation of [U-14C] 2,4-dichlorophenol was formerly achieved by a Sandmeyer reaction with p-'4C] 2,4-dichloroaniline but this sensitive step gave unreproductive yields in our hands.

We describe another route to [U-I4C] 2,4-dichlorophenol by the oxidative chlorination of !J.J-I4C] phenol. This shorter route is safer and gives satisfactory yields. The nature of the oxidizer is discussed.