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Oxidation of Phenethylamine Derivatives by Cytochrome P450 2D6: The Issue of Substrate Protonation in Binding and Catalysis †

✍ Scribed by Miller, Grover P.; Hanna, Imad H.; Nishimura, Yuki; Guengerich, F. Peter


Book ID
126997618
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
91 KB
Volume
40
Category
Article
ISSN
0006-2960

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## Abstract The roles of Phe‐120 and Glu‐222 in the oxidation of chiral substrates bunitrolol (BTL) and bufuralol (BF) by CYP2D6 are discussed. Wild‐type CYP2D6 (CYP2D6‐WT) oxidized BTL to 4‐hydroxybunitrolol (4‐OH‐BTL) with substrate enantioselectivity of (__R__)‐(+)‐BTL > (__S__)‐(−)‐BTL. The sam