Oxidation of natural targets by dioxiranes. Part 4: A novel approach to the synthesis of N-hydroxyamino acids using dioxiranes

✍ Scribed by Antonia Detomaso; Ruggero Curci

• Publisher: Elsevier Science
• Year: 2001
• Tongue: French
• Weight: 80 KB
• Volume: 42
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)02107-9

✦ Synopsis

An efficient approach to the synthesis of N-hydroxyamino acids in high enantiomeric excess is described; this involves the high-yielding selective N-hydroxylation of N-Boc protected primary amino acid esters with methyl(trifluoromethyl)dioxirane under mild conditions.