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Oxidation of methionine residues in the prion protein by hydrogen peroxide

✍ Scribed by Jesús R. Requena; Mariana N. Dimitrova; Giuseppe Legname; Susana Teijeira; Stanley B. Prusiner; Rodney L. Levine

Book ID
116177157
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
575 KB
Volume
432
Category
Article
ISSN
0003-9861

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In this article, a comprehensive picture of the oxidation of protein pharmaceuticals by peroxides is developed based on our earlier computational and experimental studies. We propose a new mechanism, the water-mediated mechanism, for the oxidation of methionine residues, and it has been shown to sat