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Oxidation of functional olefines: Synthesis of protected amino acids bearing a terminal α-hydroxyketo group

✍ Scribed by Katerine David; Alfred Greiner; Jacques Goré; Bernard Cazes


Book ID
103404614
Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
163 KB
Volume
37
Category
Article
ISSN
0040-4039

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A novel palladium(0)-catalyzed synthetic route to a series of chiral terminal allenes bearing an N-protected amino alkyl group has been developed. The palladium(0)-catalyzed reaction of mesylates of 2-bromoalk-2en-1-ols bearing an amino functionality, with diethylzinc aords the corresponding termina