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Oxidation of 2,6-Dimethylaniline by Recombinant Human Cytochrome P450s and Human Liver Microsomes

โœ Scribed by Gan, Jinping; Skipper, Paul L.; Tannenbaum, Steven R.


Book ID
121495743
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
66 KB
Volume
14
Category
Article
ISSN
0893-228X

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## Abstract Cytochrome P450 (CYP) substrates that yield fluorescent metabolites were used for rapid screening of drug metabolism activities of 13 recombinant human cytochromes P450, human liver microsomes and human hepatocytes. Reproducible results were obtained using a fluorescent plate reader (Cy