✦ LIBER ✦
Oxidant stress during reperfusion of ischemic liver: No evidence for a role of xanthine oxidase
✍ Scribed by Jacques Metzger; Srinath P. Dore; Bernhard H. Lauterburg
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 538 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0270-9139
No coin nor oath required. For personal study only.
✦ Synopsis
Oxygen-derived free radicals might play a role in the injury produced by reperfusion of ischemic organs. Since the generation of reactive oxygen species results in an increased formation of glutathione disulfide, we have attempted to document an oxidant stress during reperfusion of ischemic liver by following the hepatic production of glutathione disulfide in vivo and in the perfused rat liver. Following partial hepatic ischemia of 120 rnin duration, the plasma concentration of glutathione disulfide gradually increased from 0.8 f 0.1 to 9.1