๐”– Bobbio Scriptorium
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Overview-the role of NMR spectroscopy in epilepsy

โœ Scribed by Edward J. Novotny Jr.

Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
310 KB
Volume
13
Category
Article
ISSN
0730-725X

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โœฆ Synopsis

Nuclear magnetic resonance (NMR) spectroscopy permits noninvasive, serial measurements of several metabolites with important neurobiologic roles in localized brain regions in vivo. Over the last decade, this technique has been applied to investigations of both animals and humans with epilepsy. Several nuclei that include specific proton, phosphorus, and carbon isotopes provide NMR signals that measure specific compounds in vivo. This paper reviews the studies that have used these multinuclear NMR techniques to investigate the role of these methods in the diagnosis and pathogenesis of epilepsy.

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## Abstract Altered excitatory amino acid (EAA) neurotransmission, mediated primarily by glutamate, is a major cause of the imbalance of excitation and inhibition which characterizes both early development and epileptogenesis. Glutamate's actions are mediated by three classes of receptors: NMDA, no