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Overview of natural history, pathology, molecular genetics and management of HNPCC (Lynch syndrome)

✍ Scribed by Henry T. Lynch; Thomas Smyrk; Jane F. Lynch


Publisher
John Wiley and Sons
Year
1996
Tongue
French
Weight
653 KB
Volume
69
Category
Article
ISSN
0020-7136

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A relatively high frequency of germ-line genomic rearrangements in MLH1 and MSH2 has been reported among Lynch Syndrome (HNPCC) patients from different ethnic populations. To investigate the underlying molecular mechanisms, we characterized the DNA breakpoints of 11 germ-line deletions, six for MLH1