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Overlap in the Pharmacology of L-type Ca2+ -channel Blockers and 5-HT2 Receptor Antagonists in Rat Aorta*

โœ Scribed by E. O. Okoro


Book ID
111769841
Publisher
Pharmaceutical Press
Year
1999
Tongue
English
Weight
70 KB
Volume
51
Category
Article
ISSN
2042-7158

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The mechanism of down-regulation of L-type Ca(2+) channel (L-VOC) was investigated in rat aortic smooth muscle cells in primary culture. On culture days 3-5, the cells actively incorporated the 5-bromo-2'-deoxy-uridine (BrdU), and did not respond to K(+) depolarization nor express alpha(1C) subunit