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Overexpression of the prostaglandin E2 receptor EP2 results in enhanced skin tumor development

✍ Scribed by Sung, Y M; He, G; Hwang, D H; Fischer, S M

Book ID
110070557
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
319 KB
Volume
25
Category
Article
ISSN
0950-9232

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## Abstract Prostaglandin E~2~ (PGE~2~) has been shown to promote the development of murine skin tumors. EP1 is 1 of the 4 PGE~2~ G‐protein‐coupled membrane receptors expressed by murine keratinocytes. EP1 mRNA levels were increased ∼2‐fold after topical treatment with 12‐__O__‐tetradecanoylphorbol