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Overexpression of the mitochondrial cholesterol transport protein, StARD1, increases in vivo rates of bile acid synthesis in the rat and the mouse

โœ Scribed by Pandak, William M.; Ren, Shunlin; Marques, Dalila; Redford, Kaye; Gurley, Emiley; Bodham, Pat; Hall, Elizabeth; Gil, Gregorio; Hylemon, Phillip

Book ID
123529146
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
268 KB
Volume
124
Category
Article
ISSN
0016-5085

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Overexpression of cholesterol transporte
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Bile acid synthesis (BAS) occurs mainly via two pathways: the "neutral" pathway, which is initiated by highly regulated microsomal CYP7A1, and an "acidic" pathway, which is initiated by mitochondrial CYP27A1. Previously, we have shown that overexpression of the steroidogenic acute regulatory protein

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