Overexpression of the Helix–Loop–Helix protein Id2 blocks T cell development at multiple stages
✍ Scribed by Maureen A Morrow; Elizabeth W Mayer; Cesar A Perez; Matthew Adlam; Gerald Siu
- Book ID
- 117326592
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 315 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0161-5890
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## Abstract ## BACKGROUND. Inhibitor of DNA binding 2 (Id2), a helix‐loop‐helix protein of the inhibitor of differentiation (ID) family, is involved in hematopoiesis, mainly through interaction with the E‐family of transcription factors. Recent studies have shown that Id2 is overexpressed in some
Transcription of the genomic PHO5, PHO81 and PHO84 genes of the PHO regulon requires Pho4p and Pho2p activity, whereas transcription of PHO8 is directed by Pho4p alone. Pho4p binds to two 9-bp motifs, 5'-GCACGTGGG-3' (type 1. e.g. UASp2 of PHO5 and site D of PHO84) and 5'-GCACGTTTT-3' (type 2, e.g.