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Overexpression of the heat-shock protein 70 is associated to imatinib resistance in chronic myeloid leukemia

✍ Scribed by Pocaly, M; Lagarde, V; Etienne, G; Ribeil, J-A; Claverol, S; Bonneu, M; Moreau-Gaudry, F; Guyonnet-Duperat, V; Hermine, O; Melo, J V


Book ID
110056979
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
286 KB
Volume
21
Category
Article
ISSN
0887-6924

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## Abstract ## BACKGROUND Although various mechanisms have been recognized as being associated with the development of resistance to imatinib mesylate in vitro and in clinical situations, their relative significance and contributions remain poorly understood, as is the sequence of events leading t