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Overexpression of the cell adhesion molecule L1 is associated with metastasis in cutaneous malignant melanoma

✍ Scribed by Anka Thies; Melitta Schachner; Ingrid Moll; Jürgen Berger; Hans-Joachim Schulze; Georg Brunner; Udo Schumacher


Book ID
118606626
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
621 KB
Volume
38
Category
Article
ISSN
0959-8049

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✍ Takehito Kato; Yan Wang; Kazunori Yamaguchi; Caroline M. Milner; Ryuzaburo Shine 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 226 KB

Increased sialylation in cell surface glycoproteins is one characteristic feature of cancer cells, particularly related to their metastatic potential and invasiveness. Expression of lysosomal-type sialidase, which plays a major role in hydrolysis of such sialo-glycoproteins, is therefore considered