OVEREXPRESSION OF THE c-erbB-2 ONCOPROTEIN IN HUMAN BREAST CARCINOMAS: IMMUNOHISTOLOGICAL ASSESSMENT CORRELATES WITH GENE AMPLIFICATION
โ Scribed by Venter, DeonJ.; Kumar, Sanjeev; Tuzi, NadiaL.; Gullick, WilliamJ.
- Book ID
- 122419070
- Publisher
- The Lancet
- Year
- 1987
- Tongue
- English
- Weight
- 635 KB
- Volume
- 330
- Category
- Article
- ISSN
- 0140-6736
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Ampliยฎcation of the c-erbB2 oncogene and numerical aberrations of chromosome 17 occur in human breast carcinomas. Apocrine adenosis (AA) of the breast has been shown occasionally to have c-erbB2 overexpression and a possible premalignant potential, but little is known about cellular level genetic al
## Abstract ## BACKGROUND The angiogenic factor vascular endothelial growth factor (VEGF)โA plays an important role in breast cancer progression. However, the involvement of VEGFโC and VEGFโD, two newer members of the VEGF family, in breast carcinoma and their relationship with clinicopathologic p