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Overexpression of Presenilin-2 Enhances Apoptotic Death of Cultured Cortical Neurons

โœ Scribed by W. ARAKI; K. YUASA; S. TAKEDA; K. SHIROTANI; K. TAKAHASHI; T. TABIRA

Book ID
111396681
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
176 KB
Volume
920
Category
Article
ISSN
0890-6564

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## Abstract In utero ethanol exposure elicits apoptotic cell death in the fetal brain, and this may be mediated by oxidative stress. Our studies utilize cultured fetal rat cortical neurons and illustrate that ethanol elicits a rapid onset of oxidative stress, which culminates in mitochondrially med