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Overexpression of p53 in squamous cell carcinoma of the tongue in young patients with no known risk factors is not associated with mutations in exons 5–9

✍ Scribed by Mark W. Lingen; Kou-Wei Chang; Scott J. McMurray; Dennis B. Solt; Merrill S. Kies; Bharat B. Mittal; G. Kenneth Haines; Harold J. Pelzer

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
199 KB
Volume
22
Category
Article
ISSN
1043-3074

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Around 50% of head and neck cancers are known to have aberrations of the p53 gene. Overexpression of the mutant p53 protein can induce a specific humoral response in cancer patients. Matched saliva, serum, and tissue samples from 26 patients with histologically confirmed oral squamous and verrucous