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Overexpression of MDM2 oncoprotein correlates with possession of estrogen receptor alpha and lack of MDM2 mRNA splice variants in human breast cancer

โœ Scribed by Masao Hori; Jiro Shimazaki; Satoshi Inagawa; Masayuki Itabashi; Mitsuo Hori


Book ID
110321282
Publisher
Springer US
Year
2002
Tongue
English
Weight
144 KB
Volume
71
Category
Article
ISSN
0167-6806

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## Abstract Esophageal carcinomas from 24 patients, most of whom were smokers and consumed alcoholic beverages daily, were analyzed for mutations in exons 5โ€“8 of the __p53__ tumor suppressor gene. Mutations were identified by polymerase chain reaction amplification and direct sequencing in 12 of 24