Correlation of p53 mutations with epider
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Asuncion Esteve; Ruggero Montesano; Monica Hollstein; Theresa Lehman; Curtis C.
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Article
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1993
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John Wiley and Sons
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English
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## Abstract Esophageal carcinomas from 24 patients, most of whom were smokers and consumed alcoholic beverages daily, were analyzed for mutations in exons 5โ8 of the __p53__ tumor suppressor gene. Mutations were identified by polymerase chain reaction amplification and direct sequencing in 12 of 24