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Overexpression of MDM2, due to enhanced translation, results in inactivation of wild-type p53 in Burkitt's lymphoma cells

✍ Scribed by Capoulade, Corinne; Paillerets, Brigitte Bressac-de; Lefrère, Isabelle; Ronsin, Muriel; Feunteun, Jean; Tursz, Thomas; Wiels, Joëlle


Book ID
110061238
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
414 KB
Volume
16
Category
Article
ISSN
0950-9232

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No evidence for functional inactivation
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Inactivation of wild-type p53 during gastric carcinogenesis is usually caused by mutations within exons 5-8 of the p53 gene leading to mutated, usually immunohistochemically detectable p53 proteins. However, functional inactivation of wild-type p53, mimicking mutational inactivation, may also result