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Overexpression of Integrin-associated Protein (CD47) in Rat Kidney Treated with a Renal Carcinogen, Ferric Nitrilotriacetate

โœ Scribed by Nishiyama, Yasuyuki ;Tanaka, Tomoyuki ;Naitoh, Hiroshi ;Mori, Chisato ;Fukumoto, Manabu ;Hiai, Hiroshi ;Toyokuni, Shinya

Book ID
108581387
Publisher
Wiley (Blackwell Publishing)
Year
1997
Tongue
English
Weight
791 KB
Volume
88
Category
Article
ISSN
0910-5050

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Treatment of wistar rats with a renal carcinogen, ferric nitrilotriacetate, causes dna-protein cross-linking between thymine and tyrosine in their renal chromatin
โœ Shinya Toyokuni; Toshiaki Mori; Hiroshi Hiai; Miral Dizdaroglu ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 673 KB

Ferric nitrilotriacetate (Fe-NTA) induces renal proximal tubular damage associated with lipid peroxidation and oxidative DNA base modifications that finally leads to a high incidence of renal adenocarcinoma in rodents. In the present study, we report on the in vivo formation of DNA-protein cross-lin