Overexpression of IL-1ra gene up-regulates interleukin-1β converting enzyme (ICE) gene expression: Possible mechanism underlying IL-1β-resistance of cancer cells

Cell-type specific regulation of human i

Cell-type specific regulation of human interstitial collagenase-1 gene expression by interleukin-1β (IL-1β) in human fibroblasts and BC-8701 breast cancer cells

✍ Joni L. Rutter; Ulrike Benbow; Charles I. Coon; Constance E. Brinckerhoff 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 250 KB 👁 1 views

## ) is a potent cytokine that stimulates interstitial collagenase-1 (matrix metalloproteinase-1; MMP-1). In this study, we compared the mechanism(s) by which IL-1b induces collagenase gene expression in two very different cells, normal human foreskin fibroblasts (HFFs) and an aggressive breast ca