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Overexpression of human NOX1 complex induces genome instability in mammalian cells

โœ Scribed by Federica Chiera; Ettore Meccia; Paolo Degan; Gabriele Aquilina; Donatella Pietraforte; Maurizio Minetti; David Lambeth; Margherita Bignami

Book ID
113630444
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
984 KB
Volume
44
Category
Article
ISSN
0891-5849

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Genome instability has been associated with progression of transformed cells to high tumorigenicity. Although genome instability may result from a variety of factors, some studies suggest that DNA in the region of a chromosome rearrangement can subsequently have much higher rates of DNA deletions or