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Overexpression of fucosyltransferase IV in A431 cell line increases cell proliferation

✍ Scribed by Xuesong Yang; Zhenbo Zhang; Shuang Jia; Yuejian Liu; Xiaoqi Wang; Qiu Yan

Book ID
116307401
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
652 KB
Volume
39
Category
Article
ISSN
1357-2725

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## Abstract Lewis Y (LeY) is a carbohydrate tumor‐asssociated antigen. The majority of cancer cells derived from epithelial tissue express LeY type difucosylated oligosaccharide. Fucosyltransferase IV (FUT4) is an essential enzyme that catalyzes the synthesis of LeY oligosaccharide. Our previous st

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Fucosyltransferase IV (FUT4) is an essential enzyme that catalyzes the synthesis of difucosylated oligosaccharide LeY which is overexpressed in the cancers derived from the epithelial tissues. Our previous studies have shown that FUT4 overexpression promotes A431 cell proliferation through the MAPK