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Overexpression of FOXO1 in skeletal muscle does not alter longevity in mice

✍ Scribed by Tsuyoshi Chiba; Yasutomi Kamei; Takahiko Shimizu; Takuji Shirasawa; Aki Katsumata; Lisa Shiraishi; Satoshi Sugita; Yoshihiro Ogawa; Shinji Miura; Osamu Ezaki


Book ID
113776208
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
536 KB
Volume
130
Category
Article
ISSN
0047-6374

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## Abstract Skeletal muscle mitochondrial dysfunction has been linked to several disease states as well as the process of aging. A possible factor involved is the peroxisome proliferator‐activated receptor (PPAR) γ co‐activator 1α (PGC‐1α), a major player in the regulation of skeletal muscle mitoch