-Catenin is a component of the E-cadherin-catenin cell adhesion complex. It plays also a role in intracellular signaling and can function as an oncogene when it binds to the T-cell factor 4 (Tcf4)-binding site in the promoter region of cyclin D1 and transactivates genes after translocation to the n
✦ LIBER ✦
Overexpression of fatty acid synthase is associated with palmitoylation of Wnt1 and cytoplasmic stabilization of β-catenin in prostate cancer
✍ Scribed by Fiorentino, Michelangelo; Zadra, Giorgia; Palescandolo, Emanuele; Fedele, Giuseppe; Bailey, Dyane; Fiore, Christopher; Nguyen, Paul L; Migita, Toshiro; Zamponi, Raffaella; Di Vizio, Dolores
- Book ID
- 109885286
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 515 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0023-6837
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## Abstract HDPR1 (human homologue of Dapper) is considered as a Dishevelled (DVL) antagonist in WNT signaling. We recently reported that DVL was associated with cytoplasmic accumulation of β‐catenin in nonsmall cell lung cancer (NSCLC). Whether cytoplasmic accumulation of β‐catenin is correlated w