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Overexpression of fatty acid synthase in SKBR3 breast cancer cell line is mediated via a transcriptional mechanism

✍ Scribed by Babak Oskouian


Book ID
117469696
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
259 KB
Volume
149
Category
Article
ISSN
0304-3835

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Chemical inhibitors of fatty acid synthase (FAS) inhibit growth and induce apoptosis in several cancer cell lines in vitro and in tumor xenografts in vivo. Recently the green tea component epigallocatechin-3-gallate (EGCG) was shown to act as a natural inhibitor of FAS in chicken liver extracts. Her