Overexpression of fatty acid synthase gene activates HER1/HER2 tyrosine kinase receptors in human breast epithelial cells
β Scribed by A. Vazquez-Martin; R. Colomer; J. Brunet; R. Lupu; J. A. Menendez
- Book ID
- 108677806
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 885 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0960-7722
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## Abstract We have reported that nordihydroguaiaretic acid (NDGA) inhibits the tyrosine kinase activities of the IGFβ1 receptor (IGFβ1R) and the HER2 receptor in breast cancer cells. Herein, we studied the effects of NDGA on the growth of estrogen receptor (ER) positive MCFβ7 cells engineered to o
## Abstract Herβ2/__neu__ (__erb__Bβ2) oncogene overexpression is associated with increased tumor progression and metastasis. Fatty acid synthase (FAS), the key lipogenic enzyme responsible for the endogenous synthesis of fatty acids, has been shown to be one of the genes regulated by Herβ2/__neu__