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Overexpression of Evi-1 oncoprotein represses TGF-β signaling in colorectal cancer

✍ Scribed by Xiyun Deng; Yanna Cao; Yan Liu; Fazhi Li; Kamalanathan Sambandam; Srinivasan Rajaraman; Archibald S. Perkins; Alan P. Fields; Mark R. Hellmich; Courtney M. Townsend Jr.; E. Aubrey Thompson; Tien C. Ko

Book ID
112142367
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
494 KB
Volume
52
Category
Article
ISSN
0899-1987

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## Abstract Colorectal cancer arises from the progressive accumulation of mutations and epigenetic alterations in colon epithelial cells. Such alterations often deregulate signaling pathways that affect the formation of colon cancer, such as the Wnt, RAS‐MAPK and TGF‐β pathways. The tumor promoting